More recent studies of hepatic pathology in hyperthyroidism based on biopsy specimens in living subjects suggested subtler changes of cellular architecture, most prominently cytoplasmic clarification, decrease in ribosome numbers and density of the mitochondria and various nuclear changes such as hyperchromatism, karyolysis and alterations of nuclear size, supporting the notion of complex influences of thyroid hormones on a variety of hepatocyte functions, and modulation of a variety of target receptors [8, 20, 21]. This evidence concerns the gene TG and hyperthyroidism.