Morosini and colleagues [77] emphasize through data that they found in their study the view that in humans, at least at certain stages of pulmonary tuberculosis, there is a differential compartmentalization of IFN-γ and of the regulatory cytokine IL-12 and IL-10, where the protection factor associated with the secretion of IL-12 is present in the lungs and the component associated with immunosuppressive IL-10 secretion is predominant in peripheral blood. This evidence concerns the gene IFNG and pulmonary tuberculosis.