Following these observations, BNP or NT-proBNP has been used most commonly as diagnostic or prognostic biomarkers for a variety of cardiac disorders including myocardial remodeling [24], asymptomatic left ventricular dysfunction [25], sudden cardiac death and ventricular arrhythmia [26], and acute pulmonary embolism [27]. The gene discussed is NPPB; the disease is Ventricular arrhythmia.