We found the production of Cxcl10 and Il-6 was strongly impaired in cells lacking Prkdc−/− or Xrcc5−/− during MVA infection (Figure 7B,C) whereas the response of these cells to infection by Newcastle disease virus (NDV, an RNA virus) remained intact (Figure 7B,C). This evidence concerns the gene XRCC5 and mevalonic aciduria.