In addition, the A3 sequences were also conserved in HFMD-unrelated enteroviruses, including CVA9, CVB3, CVB5, CVB6, EV5, EV15, EV30, PV1, PV2 and PV3; albeit with two to four amino acid differences that did not affect binding to HLA presentation of the epitope to the TCR. The gene discussed is PLVAP; the disease is hand, foot and mouth disease.