CHST8 and obesity due to melanocortin 4 receptor deficiency: Similarly, variants in or nearby the susceptibility genes for obesity did not attain genome-wide significance but several - CHST8, KCTD15, MTCH2, SFRS10, SH2B1 and TMEM18 - were nominally associated with obesity-related traits, consistent with GWAS in children of European-American [63] or European ancestry [9].