Although KAI1/CD82 has been reported to upregulate cell-cell adhesion or aggregation [10], [102]–[105], associate with E-cadherin in colon cancer cells [106], and bind to a counter-receptor DARC [107], how KAI1/CD82 regulates cell-cell adhesion is poorly understood. The gene discussed is CDH1; the disease is colonic neoplasm.