TAT and HIV infectious disease: However, it is known that HIV infection is associated with increased systemic inflammation [75]–[77], and thus, it is probable that there is increased inflammation within the vasculature of other organs upon Tat treatment in our model, though the baseline fluorescence in these tissues is likely higher to begin with, due to more frequent paracellular transport of the endothelial cell layers of these organs than that of the BBB [78].