CCR2 and HIV infectious disease: As previously mentioned, in mice, Gr1 high monocytes are comparable to the CD16 high inflammatory monocyte subset within humans [48], which is expanded during HIV infection [92], while CCR-2 is the chemokine receptor for monocyte chemoattractant protein-1 (also known as CCL-2) previously demonstrated to be important for migration of leukocytes across an in vitro model of the BBB in the context of HIV [93].