After treatment of U266 (Figure 3A), RPMI 8226 (Figure 3B) and primary MM cells (Figure 3C) with NP, WEV (25 μg/ml) and WEV+NP (10 μg/ml) for 12 hours, the cells were stimulated every 15 sec with CXCL12 (250 ng/ml), and the degree of F-actin polymerization was determined using the F-actin assay and flow cytometry. The gene discussed is CXCL12; the disease is Miyoshi myopathy.