Because treatment with WEV and WEV+NP significantly decreased CXCL12-mediated chemotaxis in MM cells, we therefore investigated the phosphorylation status of AKT, PLCβ3, IκBα and ERK1/2 and the activation status of Rho-A (an important adhesion protein in MM cells) following stimulation with CXCL12. This evidence concerns the gene MAPK3 and Miyoshi myopathy.