But in the studies of neural precursor cells, glioblastoma stem cells, medulloblastoma stem cell, and myogenic cell, it has been found that hypoxia-inducible factor-1α (HIF-1α), an intracellular mediator of oxygen sensing, could interact and stabilize NICD, and activate Notch signaling pathway, to preserve these cell viability and expansion under hypoxic conditions [29], [30], [31], [32]. This evidence concerns the gene NOTCH1 and glioblastoma.