Using a genetically defined patupilone-sensitive and -resistant tumor model, we previously demonstrated that the major cytotoxic insult occurs on the tumor cell level, and that the anti-angiogenic effect of patupilone required patupilone-dependent blockage of pro-angiogenic cytokine expression and secretion from the targeted, patupilone-sensitive tumor cell, such as VEGF [6], [38]. Here, VEGFA is linked to neoplasm.