This shorter ODD includes proline564, which is hydroxylated under normoxia and thereby marked for ubiquitin-dependent degradation by the VHL-proteasome-pathway, but excludes the NO-sensitive Cys-residue at amino acid position 520 (corresponding to mouse HIF-1α aa533), which could lead to a hypoxia-independent stabilization of the reporter construct in the presence of tumor associated macrophages [39]. This evidence concerns the gene HIF1A and neoplasm.