To identify the first molecular changes in response to disulfiram and sunitinib, mRNA expression of prostate cancer oncogenes AR, PSA, ERG and MYC was studied in disulfiram (1 μM), sunitinib (5 μM) or disulfiram-sunitinib co-exposed VCaP cells at 3-hour time point. The gene discussed is AR; the disease is Familial prostate cancer.