APC and neoplasm: They are highly conserved members of the microtubule plus end-tracking proteins (+TIPs), which consist of diverse groups of microtubule-binding proteins including cytoplasmic linker protein (CLIP)-170, CLIP-associating proteins (CLASPs), adenomatous polyposis coli (APC) tumour suppressor, and also the microtubule depolymerising kinesin, MCAK (reviewed [1], [13], [14]).