ERVW-1 and lung adenocarcinoma: Here we test the hypothesis that C57BL/6 mice infected with AJEJJenv, an AAV vector expressing JSRV Env from its cognate LTR promoter in conjunction with a newly identified JSRV-derived enhancer [15], will develop lung tumors with a similar signal transduction profile to human lung adenocarcinoma, particularly that of never smokers [16].