APOA1 and serum lipopolysaccharide activity: In addition, our previous studies showed that rHDL74, which was reconstituted by mixing apoA-I (N74C) with dipalmitoyl phosphatidylcholine, had increased anti-inflammatory capability in an LPS-induced endotoxemic mouse model compared with wild-type apoA-I (apoA-Iwt) and apoA-IMilano, while rHDL228 showed hyper-proinflammation by exacerbating LPS-induced endotoxemia in mice [19].