NFKB1 and Epstein-Barr virus infection: EBV-encoded LMP1 upregulates the expression of miR-155 through activating the NFκB pathway which interacts with the promoter region of the miR-155 primary transcript [28], hence EBV infection of primary B lymphocytes leads to a sustained elevation of miR-155 and this virally-induced cellular micro RNA miR-155 plays key role in immortalization of B cells by EBV and is essential for the survival of newly generated LCLs [29].