CDKN1A and T-cell leukemia: SF induces apoptosis in several cancer cell lines and has been tested in animal models of human cancer, such as T-cell leukemia, breast, colon, and prostate cancer, by targeting caspases, PARP, p21CIP1/WAF1 (p21), p53 and Bax [21], [22], [23], [24], [25].