FISH analysis revealed prevalent deletion of the TAK1 gene in 13 of 30 (43%) AML patients (Table 1) and 2 of 9 (22%) CMML patients (data not shown), which suggests that TAK1 deletion is a common event in the pathogenesis of AML and CMML. The gene discussed is MAP3K7; the disease is chronic myelomonocytic leukemia.