The simultaneous deletion of TNFR1 did not modify the severe phenotype that developed in TAK1F/−LysMCre/Cre mice; in fact, TAK1F/−LysMCre/Cre mice on a TNFR1-null background developed splenomegaly and died at 25–43 weeks of age (Fig. 3D–F). This evidence concerns the gene TNFRSF1A and Splenomegaly.