Given that ZBTB16 (also known as PLZF) and BCL6 (ZBTB27) associate with MTG8 [19], [20] and that Kaiso and MTG16 have similar influences in cancer development, we tested for a wider structure-function relationship between the ZBTB and MTG families, which could provide insights into their roles in tumorigenesis. Here, RUNX1T1 is linked to cancer.