Overexpression of MTG8, MTG16, and MTGR1 resulted in decreased MMP-7 both at the RNA and protein levels when compared to a vector control (fold-change mRNA expression: 0.60 S.E. 0.05 (MTG8), 0.59 S.E. 0.07 (MTG16), 0.71 S.E. 0.09 (MTGR1), P<0.01 for each, Fig. 5E), and this data was confirmed in a non-cancer cell line, Cos7 (Fig. S7). The gene discussed is MMP7; the disease is cancer.