For example, the size between IL17RB-ACTR8 fusion is 4,044 bp in the reference genome sequences whereas the size of the amplified genomic fragment in AML is about 4 kb, suggesting that this fusion was generated by post-transcriptional process rather than genomic structural change; in the case of CLR-CLEC2D fusion, the size in the reference genome sequences is 31 kb but the size of the amplified genomic fragment has only 8 kb. The gene discussed is ACTR8; the disease is acute myeloid leukemia.