However, we were able to complete meta-analyses for several of the SNPs including in NAMPT, VEGF, IL8, MBL2 and TNF. In unadjusted genotype association meta-analyses using additive modeling, we observed an association between rs59744560 in NAMPT and increased risk for ALI (OR 1.33 (95% CI 1.14–1.56) p value <0.0003) and an association between rs61330082 in NAMPT and decreased risk for ALI (OR 0.86 (95% CI 0.74–1.0) p value 0.049). The gene discussed is CXCL8; the disease is acute respiratory distress syndrome.