While these results suggest a role for the adaptive immune responses in melanocyte death [25], [26], [27], there are also early suggestions that innate, or natural, immunity in vitiligo is abnormal, as suggested by Jin et al[6], who demonstrated an association between vitiligo susceptibility and genetic changes in a critical innate immunity regulator gene, the NOD-like receptor 1 (NALP1), which has recently been confirmed by immunohistochemistry [28]. Here, NLRP1 is linked to vitiligo.