However, one third of the genes were increased with suboptimal timing in aged rats, either on day 3 post-stroke (Adam17, Gpc3, Mmp14, Nid2, Tagln, Wnt5b) or on day 14 after stroke (Col4a2, Col8a1, Cthrc1, Cxcl1, Gpc3, Tgfbr2). The gene discussed is COL8A1; the disease is stroke disorder.