ACE and Stroke: Not surprisingly, the genes displaying persistent upregulation that were shared by the both age groups included some implicated in the pain response to stroke (Fstl1 and Htr2b) [14], blood pressure regulation (Ace, Calcrl, Ece1, P2rx4, Prcp), membrane potential maintenance (Enpp1 and Fxyd2), and excitatory neurotransmission (Kcnk6, Scn7a, Tpcn2).