Confirmatory genes, i.e. genes previously known to be upregulated in response to stroke, include Ccl2, Cd40 and Cd36. A strong age-specific upregulation of Cebpa, the scavenger receptor-encoding Cd36 and complement factor D-encoding Cfd, was seen in the aged rats (2- to 5-fold increases over the young rats on day 14 post-stroke). This evidence concerns the gene CD40 and stroke disorder.