In addition, clustering within the armadillo domain (codons 453–767) and around the 15 aa repeats region (codons 1020–1169), nearly one third of these indels were found at the N-terminal portion of the APC protein, disrupting 22 codons in 7 adenomas and 25 codons in 10 adenocarcinomas (Fig. 2). Here, APC is linked to adenocarcinoma.