For the other 10 genes, a total of 1,742 substitutions (612 for adenomas and 1,130 for adenocarcinomas) resulted in missense mutations for 445 codons in 10 genes and 8 adenomas and 834 codons in 10 genes and 15 adenocarcinomas, with a frequency approximately the same as that of APC (Tables 1 and 2). The gene discussed is APC; the disease is adenoma.