Seven such genes were chosen because they are located at human 5q22 (DP1 and MCC), the same locus as APC, or 18q21 (SMAD4, SMAD2, SMAD7, MBD1 and MBD2) also recurrently altered in human CRC [16]–[33]. Here, SMAD2 is linked to colorectal carcinoma.