Diabetes was introduced into these colonies of transgenic mice by breeding SMAA-GFP and SMAA-GFP-hAR expressing mice with naturally diabetic C57BL/6-Ins2Akita/J (AK) mice which carry a dominant mutation in the Mody4 locus on chromosome 7 in the insulin 2 gene [36]. The gene discussed is LYVE1; the disease is diabetes mellitus.