When Kaplan-Meier survival analysis was performed in correlation with the expression of SEMA3, Plexin or NRP members, no significant association was found except that SEMA3F-positive cases displayed longer survival and less frequent lymph node metastasis (Supplementary Fig. S1 and unpublished data). Here, SEMA3F is linked to metastatic malignant neoplasm in the lymph nodes.