When Kaplan-Meier survival analysis was performed in correlation with the expression of SEMA3, Plexin or NRP members, no significant association was found except that SEMA3F-positive cases displayed longer survival and less frequent lymph node metastasis (Supplementary Fig. S1 and unpublished data). This evidence concerns the gene NRP1 and metastatic malignant neoplasm in the lymph nodes.