Although SOX4 is reported to function as a survival factor during the development of neuro-progenitors [42] and SOX4 mediates prostaglandin A2-induced apoptosis in human hepatocellular carcinoma [43], we did not detect a significant effect on apoptosis with SOX4 depletion in pancreatic cancer cells. The gene discussed is SOX4; the disease is familial pancreatic carcinoma.