For instance, survivin promotes DNA synthesis through the activation of CDK2/cyclin E and Rb gene phosphorylation and induces cancer cell proliferation and migration (4), while VEGF has been demonstrated to be a significant promoter of tumor neovascularity; positive associations between tumor VEGF expression and aggressiveness have been demonstrated in various types of cancer (5,6). The gene discussed is RB1; the disease is neoplasm.