ACTA1 and Hepatic fibrosis: The mechanisms underlying the morphological and phenotypic changes of epithelial markers undergoing EMT in liver fibrosis include a loss of E-cadherin and cytokeratin; increased expression of FSP1, vimentin, N-cadherin and α-SMA; basement membrane component loss; and the production of interstitial-type matrix molecules, including fibronectin and type I/III collagen (10).