Human EpCAM-positive hepatocellular carcinomas (HCCs) exhibit a distinct molecular signature with the features of hepatic progenitor cells (HPCs), including the presence of known stem cell/progenitor cell markers, including cytokeratin 19 and c-Kit, whereas EpCAM-negative HCCs exhibit a gene expression profile with the features of mature hepatocytes (9). Here, EPCAM is linked to hepatocellular carcinoma.