In the present study, the expression of Oct4, Sox2 and PCNA in CD133+ glioblastoma cell-induced tumors was significantly higher than in CD133− cell-induced tumors, indicating that CD133+ glioblastoma cell-induced tumors expressed higher levels of transcription factors to maintain pluripotent features and induce proliferation. The gene discussed is PROM1; the disease is glioblastoma.