For example, intron 1 SNPs (rs6953165 and rs41298401) but not exon 6 indel or 3′ UTR poly-A polymorphisms were found to be associated with SLE in Japanese population, and they were related to differential expression of several IFN pathway genes although not IRF5 itself [26]. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.