It should be noted in the present study that the expression of both Spry1 and Spry2 isoforms in OVCAR-3 cells was significantly higher than that in the other cancer cell lines and the control group, implying that although decreased expression of Spry1 and/or Spry2 was observed more frequently amongst the ovarian cancer cell lines studied, decline in the Spry expression might not necessarily be required in all epithelial ovarian cancers. This evidence concerns the gene SPRY1 and ovarian cancer.