Related with their antidiabetic and anti-obesity effects, PPAR-γ is one of the targets of resveratrol [58], which partially mediates its antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes [150, 151] by preventing TNF-α-induced suppression of adiponectin expression [152]. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.