The CD4BDcore-specific antibodies produced by long-term survivors of HIV infection (Planque et al., 2010) or induced in mice by E-gp120 immunization (Nishiyama et al., 2009) displaying strong neutralizing activity in the PBMC assay did not impede pseudovirion entry into genetically engineered host cells expressing CD4 and chemokine receptors (TZM/Bl cells) (Paul et al., 2010). This evidence concerns the gene ITIH4 and HIV infectious disease.