ITIH4 and HIV infectious disease: Several groups reported that antibodies produced spontaneously by humans without HIV infection or vaccination bind the CD4BDcore-spanning superantigenic determinant of gp120 and synthetic peptides containing the CD4BDcore (Berberian et al., 1993; Goodglick et al., 1995; Karray and Zouali, 1997; Karray et al., 1998; Neshat et al., 2000).