APP and Alzheimer disease: Using the memory impairment produced by a microinfusion of a low dose of beta-amyloid peptide (25–35; Abeta) into the rat CA1 area of the dorsal hippocampus as a model of memory dysfunction associated with AD, we showed that an intrahippocampal infusion of bombesin completely prevented the Abeta-induced impairment in inhibitory avoidance memory (Roesler et al., 2006b; Figure 2).