The univariate conditional logistic regression analysis showed a significantly increased risk of incident T2DM for family history of diabetes, hypertension, systolic and diastolic blood pressure, FPG, 2hPG, BMI, triglycerides, CRP, tPA, PAI-1, tPA/PAI-1 complex, and VWF (Table 2). The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.