For participants with normal glucose levels, all haemostatic variables were significantly associated with incident diabetes in the univariate analysis (tPA: OR = 2.43, 95% CI 1.50-3.91; PAI-1: OR=2.66, 95% CI 1.66-4.25; tPA/PAI-1 complex: OR=3.23, 95% CI 1.93-5.41; VWF: OR=1.66, 95% CI 1.13-2.46). The gene discussed is SERPINE1; the disease is diabetes mellitus.