ERBB2 and metastatic malignant neoplasm in the lymph nodes: Yonemura et al.[28] reported that overexpression of HER-2/neu was related to tumor size, invasion depth, lymph node metastasis and TNM stage, whereas Mizutani et al.[29] found that overexpression of HER-2/neu was associated with invasion depth and liver metastasis but not with lymph node metastasis.