已有研究证实KLF4基因(Krüppel-like factor 4)和富含半胱氨酸的酸性分泌蛋白(secreted protein acidic and rich in cysteine, SPARC)与肿瘤的发生发展密切相关。本研究旨在检测KLF4和SPARC蛋白在非小细胞肺癌(non-small cell lung cancer, NSCLC)中的表达,并结合临床病理特征来探讨KLF4和SPARC的临床意义及相关性。. The gene discussed is KLF4; the disease is non-small cell lung carcinoma.