Interestingly, and in line with these observations, the expression levels of negative regulators of TLR signaling such as Ptpn11 and Pparg was conversely increased in congenics, suggesting that the arthritis gene located within the Cia5a QTL might mediate the balance between activating and inhibitory signals implicated in TLR signaling. The gene discussed is PTPN11; the disease is Arthritis.