NFKB1 and arthritic joint disease: Syk pathway members regulate several cellular processes implicated in arthritis pathogenesis and articular damage, ranging from the production of reactive oxygen species, NFκB activation and the transcription of pro-inflammatory mediators such as Il1b and Ccl2, to the cell proliferation required for the development of synovial hyperplasia, and actin cytoskeleton rearrangements [27].