Moreover, reduced RQ and enhanced VO2 were associated with protection from high fat diet-induced obesity, glucose intolerance and diabetes in mice with ablated agouti-related protein (AgRP) producing neurons and in retinaldehyde dehydrogenase 1a1 knock-out mice (Joly-Amado et al., 2012; Kiefer et al., 2012). The gene discussed is AGRP; the disease is obesity due to melanocortin 4 receptor deficiency.