Given the now well-recognized role of MSU crystals as activators of the NLRP3 inflammasome with resultant production of the pro-inflammatory cytokine IL-1β (Martinon et al., 2006), as well as the consistent documentation of neutrophilia in acute gout synovial fluid (Popa-Nita and Naccache, 2010), investigators have begun to address the extent to which NETs factor into gout pathogenesis. This evidence concerns the gene IL1B and gout.