TLR8 and systemic lupus erythematosus: Although not directly linked to SLE, LL37/cathelicidin can also complex with RNA to activate dendritic cells through TLR7 and TLR8 (Ganguly et al., 2009); this work is particularly interesting given the suggestion by Garcia-Romo and colleagues that anti-RNP antibodies and TLR7 may play a role not only in dendritic cell activation, but also in the activation of lupus neutrophils to release NETs (Garcia-Romo et al., 2011).