In SVV, anti-PR3 and anti-MPO autoantibodies have been suggested as possible triggers (Kessenbrock et al., 2009), while type I interferons as well as anti-LL37, anti-RNP, and anti-double-stranded DNA autoantibodies may play a role in SLE (Garcia-Romo et al., 2011; Lande et al., 2011; Villanueva et al., 2011). This evidence concerns the gene PRTN3 and systemic lupus erythematosus.