In addition to its anti-pathogenic activity, PTX3 also has been shown to play a role in protecting against severe inflammatory reactions in animal models of sepsis (Dias et al., 2001), seizure-induced neurodegeneration (Ravizza et al., 2001) and acute myocardial infarction (Salio et al., 2008). Here, PTX3 is linked to myocardial infarction.