Figure 6 summarizes the proposed regulatory circuit involving IFN-γ and miR29: IFN-γ, which is e.g. secreted by macrophages following diverse assaults such as infections or UV light induces a STAT1-dependent up-regulation of miR-29, which in turn can down-regulate IFN-γ expression directly and indirectly via T-bet and Eomes. This evidence concerns the gene IFNG and infection.