Accordingly, we find that IFN-γ as well as miR-29 exhibit anti-proliferative activities in melanoma cells involving down-regulation of cell cycle control players such as CDK6. The relevance of CDK6 activity for melanoma growth is further emphasized by the fact that the tumor suppressor p16INK4A (an inhibitor for CDK6 and 4) is deleted in about 50% of melanoma patients [51,52]. Here, CDKN2A is linked to melanoma.