GHRL and metabolic syndrome: In addition, it is important to acknowledge that only homozygous TRIB3 RR84 variant could decrease the level of serum obestatin in MetS individuals while heterozygous TRIB3 QR84 or homozygous TRIB3 QQ84 variants have no such, which suggested that here Q84 allele is dominant with R84 allele recessive.