Similarly, anti-STAT3 therapies, such as dominant negative STAT3 molecules, RNA interference and antisense oligonucleotides have been shown to be effective against a number of tumor types in vitro, but have yet to be tested in clinical trials, due in part to drug delivery issues including cell permeability, stability and solubility of the DNA, RNA and small molecules. The gene discussed is STAT3; the disease is neoplasm.