SNPs in the FRK/COL10A1 locus, which encodes the type X collagen alpha chain, and vascular endothelial growth factor A (VEGFA), a key regulator of neovascularization[31], have been associated with AMD as well[6], reiterating the role of extracellular matrix dysfunction and aberrant angiogenesis in AMD pathogenesis. This evidence concerns the gene VEGFA and age-related macular degeneration.