TLR4 and age-related macular degeneration: Although controversial, AMD-associated SNPs have also been identified in excision repair cross-complementing group 6 (ERCC6), a DNA repair gene[24]; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPING1), an inhibitor of the complement component C1[25]; and toll-like receptor 3 (TLR3)[26] and toll-like receptor 4 (TLR4)[27], mediators of the innate immune response.