SNPs in age-related maculopathy susceptibility 2 (ARMS2)[18-20] and HtrA serine peptidase 1 (HTRA1)[21,22], two genes in strong linkage disequilibrium on chromosome 10q26 related to extracellular matrix function, are also associated with AMD susceptibility. The gene discussed is HTRA1; the disease is age-related macular degeneration.