TP53 and esophageal squamous cell carcinoma: Independent of geographic origin, molecular changes in ESCC include frequent loss of alleles at chromosomes 3p, 5q, 9p and q, 13q, 17p, 17q or 18q, mutations in tumor suppressor genes such as TP53, and genetic and/or epigenetic alterations in CDKN2a, CCDN1, MYC1 FHIT, FEZ1, DLC1, Annexin-1, CCNB1, TP63, TP73 or DCC[9-15].