AGTR1 and diabetes mellitus: As suggested by the present observations, the capacity of green tea in modulating diabetes-induced AT1 receptor upregulation may also imply beneficial interference in the deleterious effects of excessive AT1 receptor signaling, which is central in mediating excessive tissue remodeling and alterations in renal hemodynamic and tubular functions, manifested by the development of nephropathy and hepatic fibrosis [4–27, 52, 53].