Although CT was known to have antiproliferative [30], apoptotic [32, 33], and antiangiogenic activities in cancers in normoxia [48, 49], the antitumor activity of CT in hypoxic PC-3 cells was associated with PI3K, HIF-1α and AEG-1, signaling pathways in the current study. The gene discussed is MTDH; the disease is cancer.