MTDH and cancer: AEG-1, since cloned in 2002, was known to have multibiological activities by regulating several signaling cascades such as NF-kappa B, PI3K/Akt, Wnt/ß catenin, H-Ras, c-Myc, and HIF1 alpha-related pathways in various cancer cells [23, 35, 44–46].