ANGPT1 and hepatocellular carcinoma: Recent studies show that AEG-1 is induced by hypoxia and glucose deprivation in glioblastoma [19], activates angiopoietin-1 (Ang1), matrix metalloproteinase (MMP)-2, and HIF-1 [20, 21], and plays a critical role in hepatocellular carcinoma progression as a target of microRNA-375 [22].