The results show that compared with the control group, leptin and ob-R contents in the hypothalamus of the 21-day stress group are significantly increased, which suggests that CIS can increase Leptin levels in the hypothalamus and stimulate an increase in ob-R (mainly ob-Rb) expression, and the combination specificities of the two damages the balance of hypothalamus “appetite regulation network.” Here, LEP is linked to in situ carcinoma.